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Metabolism Ketamine is metabolized via N-dealkylation to the active metabolite norketamine generally by CYP2B6 and CYP3A4 also to a lesser extent by other CYP enzymes. Norketamine undergoes hydroxylation from the cyclohexone ring to sort hydroxynorketamine compounds by way of CYP-dependent pathways, which might be conjugated with glucuronic acid an